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Thursday, August 11 • 1:40pm - 2:20pm
Dietary Management of the Apo E 4 Genotype, the True Ancestral Gene

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Much controversy continues over what constitutes the ancestral diet, yet little if any attention is given to a diet that is compatible/complimentary to the true Ancestral Genome. Approximately 30% of humans carry one or both copies of the Apolipoprotein E 4 genotype (Apo E 4). The Apo E 4 genotype is common to the great apes, but only humans can and do carry Apo E 2,3, and 4 alleles. The presence of the Apo E 4 gene has been associated with increased susceptibility to accelerated atherosclerosis, decreased longevity, susceptibility to infectious diseases, and Alzheimer’s disease, by changing the way lipoproteins interact with cell surface receptors and in regulating Amyloid Beta peptides in the brain. Because of this, we have focused our attention upon keeping the small dense oxidizable particles of LDL as low as possible via a low animal fat, high soluble fiber and resistant starch diet. We have found that limiting Triglyceride production by lessening sugars, fruits, and seeded vegetables also lowers small LDL production. We further minimize the oxidization of small LDL particles using generous amounts of polyphenol rich Olive Oil as well as the polyphenols in Resveratrol, Grape Seed Extract, Turmeric, and Pomegranate Seed Oil and Extracts. Shellfish are emphasized as the animal protein of choice if desired. Unfortunately, the Paleo Diet, with its high animal fat and protein components, produces the exact opposite effect to what needs to happen in these patients. Using this protocol, we have successfully minimized the deleterious effects of this “Ancestral Gene” in thousands of patients followed for up to 15 years, many now successfully aging into their mid to late 80’s without consequence.

avatar for Steven Gundry

Steven Gundry

MD, International Heart & Lung Institute
Steven R. Gundry, M.D., is the Medical Director of the International Heart and Lung Institute and Founder of The Centers for Restorative Medicine, Palm Springs and Santa Barbara, California and former Professor and Chairman of Cardiothoracic Surgery at Loma Linda University Medical... Read More →

Thursday August 11, 2016 1:40pm - 2:20pm MDT